Antimalarial drugs disrupt ion homeostasis in malarial parasites

Antimalarial drugs disrupt ion homeostasis in malarial parasites.

Plasmodium chabaudi malaria parasite organelles are major elements for ion homeostasis and cellular signaling and also target for antimalarial drugs. By using confocal imaging of intraerythrocytic parasites we demonstrated that the dye acridine orange (AO) is accumulated into P. chabaudi subcellular compartments. The AO could be released from the parasite organelles by collapsing the pH gradien...

Malarial Fevers and Malarial Parasites

Antimalarial drugs clear resistant parasites from partially immune hosts.

Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.

Studies on Malarial Parasites

1. Methods have been described for the preparation and sterilization of a synthetic nutrient medium which supports normal growth during one 24 hour asexual cycle of the erythrocytic form of P. knowlesi. 2. Successive subcultures with good multiplication can be carried out when whole blood or plasma is added to the medium. Data are presented from two such experiments where the sixth and seventh ...

Canadian CLL Meeting 2015 Anti-Malarial Drugs Disrupt Lysosomes in Chronic Lymphocytic Leukemia (CLL) Cells

CLL is the most common type of leukemia in the Western world and represents the most common cause of secondary immunodeficiency which can benefit from immunoglobulin replacement therapy (IgRT). While immunoglobulin replacement therapy is usually administered intravenously in a hospital or outpatient facility, the availability of subcutaneous (SCIg) administration is often very appreciated by pa...